Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells

Persistent Jak/Stat3 signal transduction plays a crucial role in tumorigenesis and immune development. Activated Jak/Stat3 signaling has been validated as a promising molecular target for cancer therapeutics discovery and development. Berbamine (BBM), a natural bis‐benzylisoquinoline alkaloid, was i...

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Bibliographische Detailangaben
Hauptverfasser: Nam, Sangkil, Xie, Jun, Perkins, Angela, Ma, Yuelong, Yang, Fan, Wu, Jun, Wang, Yan, Xu, Rong-zhen, Huang, Wendong, Horne, David A., Jove, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2012
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Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439602/
https://ncbi.nlm.nih.gov/pubmed/22717603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.05.002
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