A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling

Glioblastoma (GBM) is the most common primary brain tumor, accounting for approximately 40% of all central nervous system malignancies. Despite standard treatment consisting of surgical resection, radiotherapy and/or chemotherapy, the prognosis for GBM is poor; with a median survival of 14.6 months....

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Detalhes bibliográficos
Main Authors: Yang, Fan, Nam, Sangkil, Brown, Christine E., Zhao, Robin, Starr, Renate, Horne, David A., Malkas, Linda H., Jove, Richard, Hickey, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986211/
https://ncbi.nlm.nih.gov/pubmed/24732116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094443
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