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The in Vivo Role of Androgen Receptor SUMOylation as Revealed by Androgen Insensitivity Syndrome and Prostate Cancer Mutations Targeting the Proline/Glycine Residues of Synergy Control Motifs

The androgen receptor (AR) mediates the effects of male sexual hormones on development and physiology. Alterations in AR function are central to reproductive disorders, prostate cancer, and Kennedy disease. AR activity is influenced by post-translational modifications, but their role in AR-based dis...

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Autors principals: Mukherjee, Sarmistha, Cruz-Rodríguez, Osvaldo, Bolton, Eric, Iñiguez-Lluhí, Jorge A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438951/
https://ncbi.nlm.nih.gov/pubmed/22829593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.395210
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