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HIPPOCAMPAL ANGIOGENESIS AND PROGENITOR CELL PROLIFERATION ARE INCREASED WITH ANTIDEPRESSANT USE IN MAJOR DEPRESSION

BACKGROUND: Adult neurogenesis is coupled to angiogenesis in neurogenic niches in the dentate gyrus (DG) and increased by antidepressants in rodents. We hypothesized that, in major depressive disorder (MDD), antidepressants increase neural progenitor cells (NPCs) and capillaries in the human DG. MET...

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Detalhes bibliográficos
Main Authors: Boldrini, Maura, Hen, René, Underwood, Mark D., Rosoklija, Gorazd B., Dwork, Andrew J., Mann, J. John, Arango, Victoria
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438317/
https://ncbi.nlm.nih.gov/pubmed/22652019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2012.04.024
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