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Human DNA Polymerase ι Utilizes Different Nucleotide Incorporation Mechanisms Dependent upon the Template Base

Human DNA polymerase ι (Polι) is a member of the Y family of DNA polymerases involved in translesion DNA synthesis. Polι is highly unusual in that it possesses a high fidelity on template A, but has an unprecedented low fidelity on template T, preferring to misincorporate a G instead of an A. To und...

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Udgivet i:Mol Cell Biol
Principais autores: Washington, M. Todd, Johnson, Robert E., Prakash, Louise, Prakash, Satya
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2004
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC343821/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14701763/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.2.936-943.2004
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