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Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity
The immunopathophysiologic development of systemic autoimmunity involves numerous factors through complex mechanisms that are not fully understood. In systemic lupus erythematosus, type I IFN (IFN-I) produced by plasmacytoid dendritic cells (pDCs) critically promotes the autoimmunity through its ple...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437876/ https://ncbi.nlm.nih.gov/pubmed/22904191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206923109 |
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