Neutrophils regulate humoral autoimmunity by restricting interferon gamma production via the generation of reactive oxygen species

Here we examine the mechanism by which plasmacytoid dendritic cells (pDCs) and type I interferons promote humoral autoimmunity. In an amyloid-induced experimental autoimmune model, neutrophil depletion enhanced anti-nuclear antibody development, which correlated with heightened IFN-γ production by n...

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Publicado en:Cell Rep
Autores principales: Huang, Xinfang, Li, Jingjing, Dorta-Estremera, Stephanie, Di Domizio, Jeremy, Anthony, Scott M., Watowich, Stephanie S., Popkin, Daniel, Liu, Zheng, Brohawn, Philip, Yao, Yihong, Schluns, Kimberly S., Lanier, Lewis L., Cao, Wei
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545388/
https://ncbi.nlm.nih.gov/pubmed/26257170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.021
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