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PIP(2) controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker
Voltage-gated K(+) (Kv) channels couple the movement of a voltage sensor to the channel gate(s) via a helical intracellular region, the S4–S5 linker. A number of studies link voltage sensitivity to interactions of S4 charges with membrane phospholipids in the outer leaflet of the bilayer. Although t...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437867/ https://ncbi.nlm.nih.gov/pubmed/22891352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207901109 |
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