Competition of calcified calmodulin N lobe and PIP(2) to an LQT mutation site in Kv7.1 channel

Voltage-gated potassium 7.1 (Kv7.1) channel and KCNE1 protein coassembly forms the slow potassium current I(KS) that repolarizes the cardiac action potential. The physiological importance of the I(KS) channel is underscored by the existence of mutations in human Kv7.1 and KCNE1 genes, which cause ca...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tobelaim, William Sam, Dvir, Meidan, Lebel, Guy, Cui, Meng, Buki, Tal, Peretz, Asher, Marom, Milit, Haitin, Yoni, Logothetis, Diomedes E., Hirsch, Joel Alan, Attali, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293103/
https://ncbi.nlm.nih.gov/pubmed/28096388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612622114
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