Competition of calcified calmodulin N lobe and PIP(2) to an LQT mutation site in Kv7.1 channel

Voltage-gated potassium 7.1 (Kv7.1) channel and KCNE1 protein coassembly forms the slow potassium current I(KS) that repolarizes the cardiac action potential. The physiological importance of the I(KS) channel is underscored by the existence of mutations in human Kv7.1 and KCNE1 genes, which cause ca...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Tobelaim, William Sam, Dvir, Meidan, Lebel, Guy, Cui, Meng, Buki, Tal, Peretz, Asher, Marom, Milit, Haitin, Yoni, Logothetis, Diomedes E., Hirsch, Joel Alan, Attali, Bernard
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293103/
https://ncbi.nlm.nih.gov/pubmed/28096388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612622114
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