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Nonviral delivery of self-amplifying RNA vaccines

Despite more than two decades of research and development on nucleic acid vaccines, there is still no commercial product for human use. Taking advantage of the recent innovations in systemic delivery of short interfering RNA (siRNA) using lipid nanoparticles (LNPs), we developed a self-amplifying RN...

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Dettagli Bibliografici
Autori principali: Geall, Andrew J., Verma, Ayush, Otten, Gillis R., Shaw, Christine A., Hekele, Armin, Banerjee, Kaustuv, Cu, Yen, Beard, Clayton W., Brito, Luis A., Krucker, Thomas, O’Hagan, Derek T., Singh, Manmohan, Mason, Peter W., Valiante, Nicholas M., Dormitzer, Philip R., Barnett, Susan W., Rappuoli, Rino, Ulmer, Jeffrey B., Mandl, Christian W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437863/
https://ncbi.nlm.nih.gov/pubmed/22908294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209367109
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