Nonviral delivery of self-amplifying RNA vaccines

Despite more than two decades of research and development on nucleic acid vaccines, there is still no commercial product for human use. Taking advantage of the recent innovations in systemic delivery of short interfering RNA (siRNA) using lipid nanoparticles (LNPs), we developed a self-amplifying RN...

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Dades bibliogràfiques
Autors principals: Geall, Andrew J., Verma, Ayush, Otten, Gillis R., Shaw, Christine A., Hekele, Armin, Banerjee, Kaustuv, Cu, Yen, Beard, Clayton W., Brito, Luis A., Krucker, Thomas, O’Hagan, Derek T., Singh, Manmohan, Mason, Peter W., Valiante, Nicholas M., Dormitzer, Philip R., Barnett, Susan W., Rappuoli, Rino, Ulmer, Jeffrey B., Mandl, Christian W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437863/
https://ncbi.nlm.nih.gov/pubmed/22908294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209367109
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