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Membrane physical properties influence transmembrane helix formation
The pHLIP peptide has three states: (I) soluble in aqueous buffer, (II) bound to the bilayer surface at neutral pH, and (III) inserted as a transmembrane (TM) helix at acidic pH. The membrane insertion of pHLIP at low pH can be used to target the acidic tissues characteristic of different diseases,...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437862/ https://ncbi.nlm.nih.gov/pubmed/22908237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212665109 |
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