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Specificity in transmembrane helix–helix interactions can define a hierarchy of stability for sequence variants
The folding, stability, and oligomerization of helical membrane proteins depend in part on a precise set of packing interactions between transmembrane helices. To understand the energetic principles of these helix–helix interactions, we have used alanine-scanning mutagenesis and sedimentation equili...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC64683/ https://ncbi.nlm.nih.gov/pubmed/11724930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251367498 |
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