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Structure-based prediction of the stability of transmembrane helix–helix interactions: The sequence dependence of glycophorin A dimerization

The ability to predict the effects of point mutations on the interaction of α-helices within membranes would represent a significant step toward understanding the folding and stability of membrane proteins. We use structure-based empirical parameters representing steric clashes, favorable van der Wa...

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Autors principals: MacKenzie, Kevin R., Engelman, Donald M.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC19879/
https://ncbi.nlm.nih.gov/pubmed/9520409
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