Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia

The application of RNA interference-based gene silencing to the airway surface epithelium holds great promise to manipulate host and pathogen gene expression for therapeutic purposes. However, well-differentiated airway epithelia display significant barriers to double-stranded small-interfering RNA...

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Hlavní autoři: Krishnamurthy, Sateesh, Behlke, Mark A, Ramachandran, Shyam, Salem, Aliasger K, McCray Jr, Paul B, Davidson, Beverly L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437804/
https://ncbi.nlm.nih.gov/pubmed/23344182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.36
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