Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro

Polarized and pseudostratified primary airway epithelia present barriers that significantly reduce their transfection efficiency and the efficacy of RNA interference oligonucleotides. This creates an impediment in studies of the airway epithelium, diminishing the utility of loss-of-function as a res...

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Autori principali: Ramachandran, Shyam, Krishnamurthy, Sateesh, Jacobi, Ashley M., Wohlford-Lenane, Christine, Behlke, Mark A., Davidson, Beverly L., McCray, Paul B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2013
Soggetti:
Innovative Methodology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073929/
https://ncbi.nlm.nih.gov/pubmed/23624792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00426.2012
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