Efficient delivery of RNA interference oligonucleotides to polarized airway epithelia in vitro

Polarized and pseudostratified primary airway epithelia present barriers that significantly reduce their transfection efficiency and the efficacy of RNA interference oligonucleotides. This creates an impediment in studies of the airway epithelium, diminishing the utility of loss-of-function as a res...

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Hlavní autoři: Ramachandran, Shyam, Krishnamurthy, Sateesh, Jacobi, Ashley M., Wohlford-Lenane, Christine, Behlke, Mark A., Davidson, Beverly L., McCray, Paul B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
Témata:
Innovative Methodology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073929/
https://ncbi.nlm.nih.gov/pubmed/23624792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00426.2012
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