Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia

The delivery of biologic cargoes to airway epithelial cells is challenging due to the formidable barriers imposed by its specialized and differentiated cells. Among cargoes, recombinant proteins offer therapeutic promise but the lack of effective delivery methods limits their development. Here, we a...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Krishnamurthy, Sateesh, Wohlford-Lenane, Christine, Kandimalla, Suhas, Sartre, Gilles, Meyerholz, David K., Théberge, Vanessa, Hallée, Stéphanie, Duperré, Anne-Marie, Del’Guidice, Thomas, Lepetit-Stoffaes, Jean-Pascal, Barbeau, Xavier, Guay, David, McCray, Paul B.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817825/
https://ncbi.nlm.nih.gov/pubmed/31659165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12922-y
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