Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia

The delivery of biologic cargoes to airway epithelial cells is challenging due to the formidable barriers imposed by its specialized and differentiated cells. Among cargoes, recombinant proteins offer therapeutic promise but the lack of effective delivery methods limits their development. Here, we a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Krishnamurthy, Sateesh, Wohlford-Lenane, Christine, Kandimalla, Suhas, Sartre, Gilles, Meyerholz, David K., Théberge, Vanessa, Hallée, Stéphanie, Duperré, Anne-Marie, Del’Guidice, Thomas, Lepetit-Stoffaes, Jean-Pascal, Barbeau, Xavier, Guay, David, McCray, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817825/
https://ncbi.nlm.nih.gov/pubmed/31659165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12922-y
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