Engineered amphiphilic peptides enable delivery of proteins and CRISPR-associated nucleases to airway epithelia

The delivery of biologic cargoes to airway epithelial cells is challenging due to the formidable barriers imposed by its specialized and differentiated cells. Among cargoes, recombinant proteins offer therapeutic promise but the lack of effective delivery methods limits their development. Here, we a...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Krishnamurthy, Sateesh, Wohlford-Lenane, Christine, Kandimalla, Suhas, Sartre, Gilles, Meyerholz, David K., Théberge, Vanessa, Hallée, Stéphanie, Duperré, Anne-Marie, Del’Guidice, Thomas, Lepetit-Stoffaes, Jean-Pascal, Barbeau, Xavier, Guay, David, McCray, Paul B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817825/
https://ncbi.nlm.nih.gov/pubmed/31659165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12922-y
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