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Structural basis for leucine-rich nuclear export signal recognition by CRM1
CRM1 (also known as XPO1 and exportin 1) mediates nuclear export of hundreds of proteins through the recognition of the leucine-rich nuclear export signal (LR-NES). Here we present the 2.9Å structure of CRM1 bound to snurportin 1 (SNUPN). Snurportin 1 binds CRM1 in a bipartite manner by means of an...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437623/ https://ncbi.nlm.nih.gov/pubmed/19339969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07975 |
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