Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein

The Fanconi anemia (FA)–BRCA pathway is critical for the repair of DNA interstrand crosslinks (ICLs) and the maintenance of chromosome stability. A key step in FA-BRCA pathway activation is the covalent attachment of monoubiquitin to FANCD2 and FANCI. Monoubiquitinated FANCD2 and FANCI localize in c...

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Bibliographic Details
Main Authors: Rego, Meghan A., Kolling, Frederick W., Vuono, Elizabeth A., Mauro, Maurizio, Howlett, Niall G.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437598/
https://ncbi.nlm.nih.gov/pubmed/22855611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-410472
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