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Mesalazine Reduces Mutations in Transforming Growth Factor β Receptor II and Activin Type II Receptor by Improvement of Replication Fidelity in Mononucleotide Repeats

PURPOSE: Mesalazine (5-aminosalicylic acid, 5-ASA) has chemopreventive properties in colitis-associated cancer. In vitro, it improves replication fidelity at (CA)13 microsatellites independent of mismatch repair proficiency. Therefore, 5-ASA might be advantageous in patients with hereditary nonpolyp...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Campregher, Christoph, Honeder, Clemens, Chung, Heekyung, Carethers, John M., Gasche, Christoph
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2010
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437339/
https://ncbi.nlm.nih.gov/pubmed/20197483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2854
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