The nucleotide composition of microsatellites impacts both replication fidelity and mismatch repair in human colorectal cells

Microsatellite instability is a key mechanism of colon carcinogenesis. We have previously studied mutations within a (CA)13 microsatellite using an enhanced green fluorescent protein (EGFP)-based reporter assay that allows the distinction of replication errors and mismatch repair (MMR) activity. Her...

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Main Authors: Campregher, Christoph, Scharl, Theresa, Nemeth, Manuela, Honeder, Clemens, Jascur, Thomas, Boland, C. Richard, Gasche, Christoph
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883347/
https://ncbi.nlm.nih.gov/pubmed/20421367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq175
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