The Conserved Residue Arg46 in the N-Terminal Heptad Repeat Domain of HIV-1 gp41 Is Critical for Viral Fusion and Entry

During the process of HIV-1 fusion with the target cell, the N-terminal heptad repeat (NHR) of gp41 interacts with the C-terminal heptad repeat (CHR) to form fusogenic six-helix bundle (6-HB) core. We previously identified a crucial residue for 6-HB formation and virus entry - Lys63 (K63) in the C-t...

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Main Authors: Wang, Xiaoyi, Xiong, Weiliang, Ma, Xiaochu, Wei, Meili, Chen, Yanxia, Lu, Lu, Debnath, Asim K., Jiang, Shibo, Pan, Chungen
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436870/
https://ncbi.nlm.nih.gov/pubmed/22970321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044874
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