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Conserved Salt Bridge between the N- and C-Terminal Heptad Repeat Regions of the Human Immunodeficiency Virus Type 1 gp41 Core Structure Is Critical for Virus Entry and Inhibition

The fusogenic human immunodeficiency virus type 1 (HIV-1) gp41 core structure is a stable six-helix bundle formed by its N- and C-terminal heptad repeat sequences. Notably, the negatively charged residue Asp(632) located at the pocket-binding motif in the C-terminal heptad repeat interacts with the...

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Detalhes bibliográficos
Main Authors: He, Yuxian, Liu, Shuwen, Li, Jingjing, Lu, Hong, Qi, Zhi, Liu, Zhonghua, Debnath, Asim K., Jiang, Shibo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573276/
https://ncbi.nlm.nih.gov/pubmed/18768964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01060-08
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