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Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: ELUCIDATING THE INTRACELLULAR FATE OF THE NON-HUMAN SIALIC ACID N-GLYCOLYLNEURAMINIC ACID

The two major mammalian sialic acids are N-acetylneuraminic acid and N-glycolylneuraminic acid (Neu5Gc). The only known biosynthetic pathway generating Neu5Gc is the conversion of CMP-N-acetylneuraminic acid into CMP-Neu5Gc, which is catalyzed by the CMP-Neu5Ac hydroxylase enzyme. Given the irrevers...

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Détails bibliographiques
Auteurs principaux: Bergfeld, Anne K., Pearce, Oliver M. T., Diaz, Sandra L., Pham, Tho, Varki, Ajit
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436522/
https://ncbi.nlm.nih.gov/pubmed/22692205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.363549
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