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Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose

N-Glycolylneuraminic acid (Neu5Gc) is a non-human sialic acid, which may play a significant role in human pathologies, such as cancer, and vascular disease. Further studies into the role of Neu5Gc in human disease is hindered by limited sources of this carbohydrate. Using a chemoenzymatic approach,...

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Detalhes bibliográficos
Main Authors: Pearce, Oliver M. T., Varki, Ajit
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898718/
https://ncbi.nlm.nih.gov/pubmed/20452577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carres.2010.04.003
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