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The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status

SIRT1, a NAD(+)-dependent protein deacetylase, is an important regulator in cellular stress response and energy metabolism. While the list of SIRT1 substrates is growing, how the activity of SIRT1 is regulated remains unclear. We have previously reported that SIRT1 is activated by phosphorylation at...

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Bibliografiset tiedot
Päätekijät: Guo, Xiumei, Kesimer, Mehmet, Tolun, Gökhan, Zheng, Xunhai, Xu, Qing, Lu, Jing, Sheehan, John K., Griffith, Jack D., Li, Xiaoling
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435561/
https://ncbi.nlm.nih.gov/pubmed/22962634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00640
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