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Mechanism of Sirt1 NAD(+)-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation
The sirtuin family of proteins catalyze the NAD(+)-dependent deacylation of acyl-lysine residues. Humans encode seven sirtuins (Sirt1–7), and recent studies have suggested that post-translational modification of Sirt1 by cysteine S-nitrosation correlates with increased acetylation of Sirt1 deacetyla...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5207242/ https://ncbi.nlm.nih.gov/pubmed/27756843 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.754655 |
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