Raft-like microdomains play a key role in mitochondrial impairment in lymphoid cells from patients with Huntington's disease

Huntington's disease (HD) is a genetic neurodegenerative disease characterized by an exceedingly high number of contiguous glutamine residues in the translated protein, huntingtin (Htt). The primary site of cell toxicity is the nucleus, but mitochondria have been identified as key components of...

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Autores principales: Ciarlo, Laura, Manganelli, Valeria, Matarrese, Paola, Garofalo, Tina, Tinari, Antonella, Gambardella, Lucrezia, Marconi, Matteo, Grasso, Maria, Misasi, Roberta, Sorice, Maurizio, Malorni, Walter
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2012
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435539/
https://ncbi.nlm.nih.gov/pubmed/22773688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M026062
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