Raft-like microdomains play a key role in mitochondrial impairment in lymphoid cells from patients with Huntington's disease

Huntington's disease (HD) is a genetic neurodegenerative disease characterized by an exceedingly high number of contiguous glutamine residues in the translated protein, huntingtin (Htt). The primary site of cell toxicity is the nucleus, but mitochondria have been identified as key components of...

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Hlavní autoři: Ciarlo, Laura, Manganelli, Valeria, Matarrese, Paola, Garofalo, Tina, Tinari, Antonella, Gambardella, Lucrezia, Marconi, Matteo, Grasso, Maria, Misasi, Roberta, Sorice, Maurizio, Malorni, Walter
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2012
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435539/
https://ncbi.nlm.nih.gov/pubmed/22773688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M026062
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