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Correlated Electrostatic Mutations Provide a Reservoir of Stability in HIV Protease
HIV protease, an aspartyl protease crucial to the life cycle of HIV, is the target of many drug development programs. Though many protease inhibitors are on the market, protease eventually evades these drugs by mutating at a rapid pace and building drug resistance. The drug resistance mutations, cal...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3435258/ https://ncbi.nlm.nih.gov/pubmed/22969420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002675 |
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