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Accessory Mutations Maintain Stability in Drug Resistant HIV-1 Protease

The underlying mechanisms driving the evolution of drug resistance in HIV are only partially understood. We investigated the evolutionary cost of the major resistance mutations in HIV-1 protease in terms of protein stability. The accumulation of resistance mutations destabilizes the protease, limiti...

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Autors principals: Chang, Max W., Torbett, Bruce E.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139113/
https://ncbi.nlm.nih.gov/pubmed/21762813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.038
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