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Accessory Mutations Maintain Stability in Drug Resistant HIV-1 Protease
The underlying mechanisms driving the evolution of drug resistance in HIV are only partially understood. We investigated the evolutionary cost of the major resistance mutations in HIV-1 protease in terms of protein stability. The accumulation of resistance mutations destabilizes the protease, limiti...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3139113/ https://ncbi.nlm.nih.gov/pubmed/21762813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.038 |
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