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Pairwise and higher-order correlations among drug-resistance mutations in HIV-1 subtype B protease

BACKGROUND: The reaction of HIV protease to inhibitor therapy is characterized by the emergence of complex mutational patterns which confer drug resistance. The response of HIV protease to drugs often involves both primary mutations that directly inhibit the action of the drug, and a host of accesso...

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Detalhes bibliográficos
Main Authors: Haq, Omar, Levy, Ronald M, Morozov, Alexandre V, Andrec, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745583/
https://ncbi.nlm.nih.gov/pubmed/19758465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-10-S8-S10
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