The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation

The proinflammatory cytokine interleukin-1 (IL-1) signals via type I IL-1 receptor (IL-1RI) and IL-1 receptor accessory protein (IL1RAP), which leads to activation of the transcription factor NF-κB and induction of a range of downstream proteins involved in inflammatory and immune responses. Here, w...

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, Rui, Li, Mi, Zhang, Yu, Zhou, Qian, Shu, Hong-Bing
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435212/
https://ncbi.nlm.nih.gov/pubmed/22904187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1205246109
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