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Randomized Phase II Trial Designs With Biomarkers

Efficient development of targeted therapies that may only benefit a fraction of patients requires clinical trial designs that use biomarkers to identify sensitive subpopulations. Various randomized phase III trial designs have been proposed for definitive evaluation of new targeted treatments and th...

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Bibliografiske detaljer
Main Authors: Freidlin, Boris, McShane, Lisa M., Polley, Mei-Yin C., Korn, Edward L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434989/
https://ncbi.nlm.nih.gov/pubmed/22869885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.43.3946
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