A Chimeric Toxin Vaccine Protects against Primary and Recurrent Clostridium difficile Infection

The global emergence of Clostridium difficile infection (CDI) has contributed to the recent surge in severe antibiotic-associated diarrhea and colonic inflammation. C. difficile produces two homologous glucosylating exotoxins, TcdA and TcdB, both of which are pathogenic and require neutralization to...

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Autori principali: Wang, Haiying, Sun, Xingmin, Zhang, Yongrong, Li, Shan, Chen, Kevin, Shi, Lianfa, Nie, Weijia, Kumar, Raj, Tzipori, Saul, Wang, Jufang, Savidge, Tor, Feng, Hanping
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Microbial Immunity and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434558/
https://ncbi.nlm.nih.gov/pubmed/22615245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00215-12
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