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EphrinA1 Is Released in Three Forms from Cancer Cells by Matrix Metalloproteases

EphrinA1 is a glycosylphosphatidylinositol (GPI)-linked ligand for the EphA2 receptor, which is overexpressed in glioblastoma (GBM), among other cancers. Activation of the receptor by ephrinA1 leads to a suppression of oncogenic properties of GBM cells. We documented that a monomeric functional form...

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Autores principales: Beauchamp, Amanda, Lively, Mark O., Mintz, Akiva, Gibo, Denise, Wykosky, Jill, Debinski, Waldemar
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434542/
https://ncbi.nlm.nih.gov/pubmed/22688511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06791-11
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