ERα Phosphorylation at Y537 by Src Triggers E6-AP-ERα Binding, ERα Ubiquitylation, Promoter Occupancy, and Target Gene Expression

Many transcription factors undergo transcription-coupled proteolysis. Although ligand binding activates ubiquitin proteolysis of estrogen receptor α (ERα), mechanisms governing this and its relationship to transcriptional activation were unclear. Data presented link cross talk between the Src kinase...

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Autors principals: Sun, Jun, Zhou, Wen, Kaliappan, Kosalai, Nawaz, Zafar, Slingerland, Joyce M.
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2012
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434528/
https://ncbi.nlm.nih.gov/pubmed/22865929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1140
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