Src promotes estrogen-dependent estrogen receptor α proteolysis in human breast cancer

Estrogen drives both transcriptional activation and proteolysis of estrogen receptor α (ERα; encoded by ESR1). Here we observed variable and overlapping ESR1 mRNA levels in 200 ERα-negative and 50 ERα-positive primary breast cancers examined, which suggests important posttranscriptional ERα regulati...

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Detalhes bibliográficos
Main Authors: Chu, Isabel, Arnaout, Angel, Loiseau, Sophie, Sun, Jun, Seth, Arun, McMahon, Chris, Chun, Kathy, Hennessy, Bryan, Mills, Gordon B., Nawaz, Zafar, Slingerland, Joyce M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906730/
https://ncbi.nlm.nih.gov/pubmed/17627304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI21739
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