Загрузка...
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
Mammalian target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation, and survival via mTOR complex 1 (mTORC1) and mTORC2. The mTOR pathway is often aberrantly activated in cancers. While hypoxia, nutrient deprivation, and DNA damage restrain mTORC1 activity, multi...
Сохранить в:
| Главные авторы: | , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2011
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3069769/ https://ncbi.nlm.nih.gov/pubmed/21490404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44145 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|