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Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
Mammalian target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation, and survival via mTOR complex 1 (mTORC1) and mTORC2. The mTOR pathway is often aberrantly activated in cancers. While hypoxia, nutrient deprivation, and DNA damage restrain mTORC1 activity, multi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3069769/ https://ncbi.nlm.nih.gov/pubmed/21490404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44145 |
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