Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

Mammalian target of rapamycin (mTOR) is a PI3K-related kinase that regulates cell growth, proliferation, and survival via mTOR complex 1 (mTORC1) and mTORC2. The mTOR pathway is often aberrantly activated in cancers. While hypoxia, nutrient deprivation, and DNA damage restrain mTORC1 activity, multi...

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Bibliographic Details
Main Authors: Wander, Seth A., Hennessy, Bryan T., Slingerland, Joyce M.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2011
Subjects:
Science in Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069769/
https://ncbi.nlm.nih.gov/pubmed/21490404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44145
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