Insights into Phosphate Cooperativity and Influence of Substrate Modifications on Binding and Catalysis of Hexameric Purine Nucleoside Phosphorylases

The hexameric purine nucleoside phosphorylase from Bacillus subtilis (BsPNP233) displays great potential to produce nucleoside analogues in industry and can be exploited in the development of new anti-tumor gene therapies. In order to provide structural basis for enzyme and substrates rational optim...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: de Giuseppe, Priscila O., Martins, Nadia H., Meza, Andreia N., dos Santos, Camila R., Pereira, Humberto D’Muniz, Murakami, Mario T.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434127/
https://ncbi.nlm.nih.gov/pubmed/22957058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044282
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