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Normal T cell homeostasis: the conversion of naïve cells into memory-phenotype cells

Covert TCR signals from contact with self-ligands synergize with IL-7-induced anti-apoptotic signals to promote survival of naïve T cells in a resting state. The level of background TCR signaling in naïve T cells is set by post-thymic TCR tuning and operates at an intensity just below that required...

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Detalhes bibliográficos
Main Authors: Sprent, Jonathan, Surh, Charles D
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434123/
https://ncbi.nlm.nih.gov/pubmed/21739670
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