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TCR-dependent regulation of lipid rafts controls naive CD8(+) cell homeostasis
TCR contact with self-MHC ligands in vivo keeps T cells alive and is shown here to cause naive CD8(+) cells, but not CD4(+) cells, to be hypersensitive to certain γ(c) cytokines, notably IL-2, IL-15 and IL-7. Hypersensitivity of CD8(+) cells to IL-2 is dependent on a low-level TCR signal, associated...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2830358/ https://ncbi.nlm.nih.gov/pubmed/20137986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.11.014 |
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