Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels

Human ether-a-go-go–related gene (hERG) potassium channels exhibit unique gating kinetics characterized by unusually slow activation and deactivation. The N terminus of the channel, which contains an amphipathic helix and an unstructured tail, has been shown to be involved in regulation of this slow...

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Bibliographic Details
Main Authors: Tan, Peter S., Perry, Matthew D., Ng, Chai Ann, Vandenberg, Jamie I., Hill, Adam P.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434099/
https://ncbi.nlm.nih.gov/pubmed/22891279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110761
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