A metabolic prosurvival role for PML in breast cancer

Cancer cells exhibit an aberrant metabolism that facilitates more efficient production of biomass and hence tumor growth and progression. However, the genetic cues modulating this metabolic switch remain largely undetermined. We identified a metabolic function for the promyelocytic leukemia (PML) ge...

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Hlavní autoři: Carracedo, Arkaitz, Weiss, Dror, Leliaert, Amy K., Bhasin, Manoj, de Boer, Vincent C.J., Laurent, Gaelle, Adams, Andrew C., Sundvall, Maria, Song, Su Jung, Ito, Keisuke, Finley, Lydia S., Egia, Ainara, Libermann, Towia, Gerhart-Hines, Zachary, Puigserver, Pere, Haigis, Marcia C., Maratos-Flier, Elefteria, Richardson, Andrea L., Schafer, Zachary T., Pandolfi, Pier P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433768/
https://ncbi.nlm.nih.gov/pubmed/22886304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI62129
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