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Molecular chaperones regulate p53 and suppress senescence programs

Many types of cancer cells constitutively express major molecular chaperones at high levels. Recent findings demonstrate that specific depletion of individual chaperones, including various members of the Hsp70 family, small heat shock proteins, or VCP/p97, leads to activation of p53 pathway and subs...

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Autors principals: Sherman, Michael, Gabai, Vladimir, O’Callaghan, Cornelia, Yaglom, Julia
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433766/
https://ncbi.nlm.nih.gov/pubmed/17555746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.05.036
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